Targeting IL-11 signaling in colon cancer

Abstract excerpt

The development of Colorectal cancer (CRC), the fourth most common cause of malignancy worldwide, is driven by the sequential accumulation of genetic changes. In the Western world, more than 80 % of sporadic CRC cases arise from aberrant activation of the WNT-pathway, including mutations in the adenomatous polyposis coli (APC) tumor suppressor gene and CTNNB1 transcription factor, and followed by mutations in...

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