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Article

Human prostate cancer initiating cells isolated directly from localized cancer do not form prostaspheres in primary culture

6 Mar 2012

Abstract excerpt

BACKGROUND: Recent experimental studies suggest that hierarchical expansion from a minor population of cancer cells with an unlimited self-renewal capacity, termed cancer initiating cells (CICs), drives both lethality and heterogeneity of prostate cancer. Human prostate CICs have been established from only two primary prostate cancer patients, with the remaining established CIC lines being derived from metastatic...

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PMID: 22396312
DOI: 10.1002/pros.22503

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