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Genomic profiling of tumor initiating prostatospheres

1 Jan 2010

Abstract excerpt

BACKGROUND: The cancer stem cell (CSC) hypothesis proposes that a population of tumor cells bearing stem cell properties is responsible for the origin and maintenance of tumors. Normal and cancer stem cells possess the ability to grow in vitro as self-renewing spheres, but the molecular basis of this phenotype remains largely unknown. We intended to establish a comprehensive culture system to grow prostatospheres...

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PMID: 20500816
DOI: 10.1186/1471-2164-11-324

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