Article
Role of low-frequency HIV-1 variants in failure of nevirapine-containing antiviral therapy in women previously exposed to single-dose nevirapine.
Proceedings of the National Academy of Sciences of the United States of America - 31 May 2011
Boltz Valerie F, Zheng Yu, Lockman Shahin, Hong Feiyu, Halvas Elias K, McIntyre James, Currier Judith S, Chibowa Margret C, Kanyama Cecelia, Nair Apsara, Owino-Ong'or Willis, Hughes Michael, Coffin John M, Mellors John W
Abstract excerpt
In the OCTANE/A5208 study of initial antiretroviral therapy (ART) in women exposed to single-dose nevirapine (sdNVP) ≥ 6 mo earlier, the primary endpoint (virological failure or death) was significantly more frequent in the NVP-containing treatment arm than in the lopinavir/ritonavir-containing treatment arm. Detection of NVP resistance in plasma virus at study entry by standard population genotype was strongly...
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