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Article

Slower clearance of nevirapine resistant virus in infants failing extended nevirapine prophylaxis for prevention of mother-to-child HIV transmission.

AIDS research and human retroviruses - 1 Aug 2011

Persaud Deborah, Bedri Abubaker, Ziemniak Carrie, Moorthy Anitha, Gudetta Berhanu, Abashawl Aida, Mengistu Yohannes, Omer Saad B, Isehak Abdulhamid, Kumbi Solomon, Adamu Rahel, Lulseged Sileshi, Ashworth Roxann, Hassen Elham, Ruff Andrea

Abstract excerpt

Nevirapine resistance mutations arise commonly following single or extended-dose nevirapine (ED-NVP) prophylaxis to prevent mother-to-child transmission (PMTCT) of human immunodeficiency virus (HIV), but decay within 6-12 months of single-dose exposure. Use of ED-NVP prophylaxis in infants is expected to rise, but data on decay of nevirapine resistance mutations in infants in whom ED-NVP failed remain limited. We...

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Identifiers

PMID: 21241214
DOI: 10.1089/aid.2010.0346
PMCID: PMC3149453

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