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Epigenetic silencing ofHNF1Aassociates with changes in the composition of the human plasmaN-glycome

1 Feb 2012

Abstract excerpt

Protein glycosylation is a ubiquitous modification that affects the structure and function of proteins. Our recent genome wide association study identified transcription factor HNF1A as an important regulator of plasma protein glycosylation. To evaluate the potential impact of epigenetic regulation of HNF1A on protein glycosylation we analyzed CpG methylation in 810 individuals. The association between...

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PMID: 22395466
DOI: 10.4161/epi.7.2.18918

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