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Article

Development of high content imaging methods for cell death detection in human pluripotent stem cell-derived cardiomyocytes.

Journal of cardiovascular translational research - 1 Oct 2012

Mioulane Maxime, Foldes Gabor, Ali Nadire N, Schneider Michael D, Harding Sian E

Abstract excerpt

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CM) are being investigated as a new source of cardiac cells for drug safety assessment. We developed a novel scalable high content microscopy-based method for the detection of cell death in hPSC-CM that can serve for future predictive in vitro cardio-toxicological screens. Using rat neonatal ventricular cardiomyocytes (RVNC) or hPSC-CM, assays for nuclear...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22896035
DOI: 10.1007/s12265-012-9396-1
PMCID: PMC3447146

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