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Article

Analysis of binding sites on complement factor I using artificial N-linked glycosylation.

The Journal of biological chemistry - 20 Apr 2012

Sanchez-Gallego Jose I, Groeneveld Tom W L, Krentz Stefanie, Nilsson Sara C, Villoutreix Bruno O, Blom Anna M

Abstract excerpt

Factor I (FI) is a serine protease that inhibits all complement pathways by degrading activated complement components C3b and C4b. FI functions only in the presence of several cofactors, such as factor H, C4b-binding protein, complement receptor 1, and membrane cofactor protein. FI is composed of two chains linked by a disulfide bridge; the light chain comprises only the serine protease (SP) domain, whereas the...

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Identifiers

PMID: 22393059
DOI: 10.1074/jbc.M111.326298
PMCID: PMC3340171

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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