Article
Site-1 protease is required for cartilage development in zebrafish.
Proceedings of the National Academy of Sciences of the United States of America - 25 Nov 2003
Schlombs Kornelia, Wagner Thomas, Scheel Jochen
Abstract excerpt
gonzo (goz) is a zebrafish mutant with defects in cartilage formation. The goz phenotype comprises cartilage matrix defects and irregular chondrocyte morphology. Expression of endoderm, mesoderm, and cartilage marker genes is, however, normal, indicating a defect in chondrocyte morphogenesis. The mutated gene responsible for the goz phenotype, identified by positional cloning and confirmed by phosphomorpholino...
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