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Article

Energetic evaluation of binding modes in the C3d and Factor H (CCP 19-20) complex.

Protein science : a publication of the Protein Society - 1 May 2015

E S Harrison Reed, Gorham Ronald D, Morikis Dimitrios

Abstract excerpt

As a part of innate immunity, the complement system relies on activation of the alternative pathway (AP). While feed-forward amplification generates an immune response towards foreign surfaces, the process requires regulation to prevent an immune response on the surface of host cells. Factor H (FH) is a complement protein secreted by native cells to negatively regulate the AP. In terms of structure, FH is...

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Identifiers

PMID: 25628052
DOI: 10.1002/pro.2650
PMCID: PMC4420527

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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