Article
SLC25A48 influences plasma levels of choline and localizes to the inner mitochondrial membrane.
Molecular genetics and metabolism - 1 Jan 2000
Bernard David J, Pangilinan Faith, Mendina Caitlin, Desporte Tara, Wincovitch Stephen M, Walsh Darren J, Porter Richard K, Molloy Anne M, Shane Barry, Brody Lawrence C
Abstract excerpt
Choline contributes to the biogenesis of methyl groups, neurotransmitters, and cell membranes. Our genome-wide association study (GWAS) of circulating choline in 2228 college students found that alleles in SLC25A48 (rs6596270) influence choline concentrations in men (p = 9.6 × 10-8), but not women. Previously, the subcellular location and function of SLC25A48 were unknown. Using super-resolution...
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