Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Choline metabolic pathway gene polymorphisms and risk for Down syndrome: An association study in a population with folate-homocysteine metabolic impairment.

European journal of clinical nutrition - 1 Jan 2017

Jaiswal S K, Sukla K K, Chauhan A, Lakhotia A R, Kumar A, Rai A K

Abstract excerpt

BACKGROUND/OBJECTIVES: Choline is an essential nutrient involved in one-carbon metabolism, but its role in mechanisms underlying meiotic non-disjunction is poorly known. The relationship between folate-homocysteine metabolic pathway gene polymorphism and Down syndrome (DS) risk has been widely analyzed, but there are limited reports on its correlation with choline metabolism. In the present case-control...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Choline
Share to Down Syndrome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Folic Acid

Share to Genetic Association Studies

Share to Homocysteine

Share to Metabolic Networks and Pathways

Share to Mothers

Share to Odds Ratio

Source

Identifiers

PMID: 27677362
DOI: 10.1038/ejcn.2016.190

Genes

BHMT
CHDH
PEMT
MTHFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Choline metabolic pathway gene polymorphisms and risk for Down syndrome: An association study in a population with folate-homocysteine metabolic impairment.PMID 27677362Read ↗

Folate metabolism gene polymorphisms MTHFR C677T and A1298C and risk for Down syndrome offspring: a meta-analysis.Semantic proximity Read ↗

MTHFR gene polymorphism and associated nutritional deficiency in the etiology and pathogenesis of Down syndromeSemantic proximity Read ↗

Role of folate-homocysteine pathway gene polymorphisms and nutritional cofactors in Down syndrome: A triad study.Semantic proximity Read ↗

Maternal gene polymorphisms involved in folate metabolism and the risk of having a Down syndrome offspring: a meta-analysis.Semantic proximity Read ↗

Genetic polymorphisms involved in folate metabolism and elevated plasma concentrations of homocysteine: maternal risk factors for Down syndrome in Brazil.Semantic proximity Read ↗

Maternal methylenetetrahydrofolate reductase C677T polymorphism and down syndrome risk: a meta-analysis from 34 studies.Semantic proximity Read ↗

The genetics of folate metabolism and maternal risk of birth of a child with Down syndrome and associated congenital heart defectsSemantic proximity Read ↗

[The relationship between polymorphism of gene involved in folate metabolism, homocysteine level and risk of Down syndrome].Semantic proximity Read ↗

Association between MTHFR C677T and A1298C gene polymorphisms and maternal risk for Down syndrome: A protocol for systematic review and/or meta-analysis.Semantic proximity Read ↗

Relationship between polymorphisms in genes involved in homocysteine metabolism and maternal risk for Down syndrome in Brazil.Semantic proximity Read ↗

Maternal MTHFR polymorphism (677 C-T) and risk of Down's syndrome child: meta-analysis.Semantic proximity Read ↗

Genetic polymorphisms involved in folate metabolism and maternal risk for down syndrome: a meta-analysis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.