Article
The use of next generation sequencing technology to study the effect of radiation therapy on mitochondrial DNA mutation.
Mutation research - 15 May 2012
Guo Yan, Cai Qiuyin, Samuels David C, Ye Fei, Long Jirong, Li Chung-I, Winther Jeanette F, Tawn E Janet, Stovall Marilyn, Lähteenmäki Päivi, Malila Nea, Levy Shawn, Shaffer Christian, Shyr Yu, Shu Xiao-Ou, Boice John D
Abstract excerpt
The human mitochondrial genome has an exclusively maternal mode of inheritance. Mitochondrial DNA (mtDNA) is particularly vulnerable to environmental insults due in part to an underdeveloped DNA repair system, limited to base excision and homologous recombination repair. Radiation exposure to the ovaries may cause mtDNA mutations in oocytes, which may in turn be transmitted to offspring. We hypothesized that the...
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