Article
Changes in the human mitochondrial genome after treatment of malignant disease.
Mutation research - 9 Apr 2003
Wardell Theresa M, Ferguson Elaine, Chinnery Patrick F, Borthwick Gillian M, Taylor Robert W, Jackson Graham, Craft Alan, Lightowlers Robert N, Howell Neil, Turnbull Douglass M
Abstract excerpt
Mitochondrial DNA (mtDNA) is the only extrachromosomal DNA in human cells. The mitochondrial genome encodes essential information for the synthesis of the mitochondrial respiratory chain. Inherited defects of this genome are an important cause of human disease. In addition, the mitochondrial genome seems to be particularly prone to DNA damage and acquired mutations may have a role in ageing, cancer and...
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