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Article

Could age modify the effect of genetic variants in IL6 and TNF-α genes in multiple myeloma?

Leukemia research - 1 May 2012

Martino Alessandro, Buda Gabriele, Maggini Valentina, Lapi Francesco, Lupia Antonella, Di Bello Domenica, Orciuolo Enrico, Galimberti Sara, Barale Roberto, Petrini Mario, Rossi Anna Maria

Abstract excerpt

Cytokines play a central role in multiple myeloma (MM) pathogenesis thus genetic variations within cytokines coding genes could influence MM susceptibility and therapy outcome. We investigated the impact of 8 SNPs in these genes in 202 MM cases and 235 controls also evaluating their impact on therapy outcome in a subset of 91 patients. Despite the overall negative findings, we found a significant age-modified...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22387051
DOI: 10.1016/j.leukres.2012.02.009

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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