Article
Gender-specific association of methylenetetrahydrofolate reductase gene polymorphisms with sporadic amyotrophic lateral sclerosis.
Genetic testing and molecular biomarkers - 1 Jul 2012
Sazci Ali, Ozel Mavi Deniz, Emel Ergul, Idrisoglu Halil Atilla
Abstract excerpt
Studies have revealed that elevated homocysteine levels can cause damage to motor neurons through multiple neurotoxic mechanisms, thus leading to the pathogenesis of amyotrophic lateral sclerosis (ALS). One way by which homocysteine levels are increased in the body is the consequence of methylenetetrahydrofolate reductase (MTHFR) gene polymorphisms. Therefore, to address this question, we studied the MTHFR C677T...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.