Article
Influence of GSTP1 rs1695 polymorphism on survival in male patients' amyotrophic lateral sclerosis: a genetic association study in Brazilian population.
Molecular biology reports - 1 Feb 2022
de Sousa Barros Jéssica Barletto, de Faria Santos Kamilla, da Cruz Pereira Bento Dhiogo, Prado Assunção Leandro do, da Silva Santos Rodrigo, da Silva Reis Angela Adamski
Abstract excerpt
BACKGROUND: Glutathione S-transferase Pi (GSTP1) enzyme has a major antioxidant effect on the central nervous system (CNS), where it acts against oxidative damage, an established risk factor for amyotrophic lateral sclerosis (ALS). Hence, the purpose of this study was to evaluate a possible relationship between GSTP1 rs1695 polymorphism and the survival rate of male ALS patients, which is the gender more affected...
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