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Article

Functional significance of aldehyde dehydrogenase ALDH1A1 to the nigrostriatal dopamine system.

Brain research - 23 Aug 2011

Anderson David W, Schray Rebecca C, Duester Gregg, Schneider Jay S

Abstract excerpt

Aldehyde dehydrogenase 1A1 (ALDH1A1) is a member of a superfamily of detoxification enzymes found in various tissues that participate in the oxidation of both aliphatic and aromatic aldehydes. In the brain, ALDH1A1 participates in the metabolism of catecholamines including dopamine (DA) and norepinephrine, but is uniquely expressed in a subset of dopaminergic (DAergic) neurons in the ventral mesencephalon where...

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Identifiers

PMID: 21784415
DOI: 10.1016/j.brainres.2011.06.051
PMCID: PMC3995134

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