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Article

Influence of adult age on the total and free clearance and protein binding of (R)- and (S)-warfarin.

British journal of clinical pharmacology - 1 Nov 2012

Jensen Berit Packert, Chin Paul Ken Leong, Roberts Rebecca Lee, Begg Evan James

Abstract excerpt

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT: Hepatic drug clearance is thought to be reduced with age. However for highly protein bound drugs, which are cleared by capacity-limited metabolism, studies on total clearance have been conflicting. The hypothesis that protein binding decreases with age has been used to explain this. Warfarin is a highly protein bound drug, which is cleared by capacity-limited metabolism....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22380743
DOI: 10.1111/j.1365-2125.2012.04259.x
PMCID: PMC3495144

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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