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Article

Application of Physiologically Based Pharmacokinetic Modeling to Optimize Assessment of Age-Related Fluoxetine Accumulation in the Elderly.

CPT: pharmacometrics & systems pharmacology - 1 Sept 2026

Jang Yoo Jin, Heo Dong-Gyu, Hong Eunjin

Abstract excerpt

This study quantified age-related differences in fluoxetine pharmacokinetics and evaluated the influence of CYP2D6 phenotype using physiologically based pharmacokinetic (PBPK) modeling integrated with clinical therapeutic drug monitoring data. A PBPK model for fluoxetine and its active metabolite norfluoxetine was implemented in the Simcyp Simulator and verified using published pharmacokinetic studies....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42631653
DOI: 10.1002/psp4.70319
PMCID: PMC13499506

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