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Article

Early and prolonged antiretroviral therapy is associated with an HIV-1-specific T-cell profile comparable to that of long-term non-progressors.

PloS one - 5 Apr 2011

Cellerai Cristina, Harari Alexandre, Stauss Hans, Yerly Sabine, Geretti Anna-Maria, Carroll Anne, Yee Thynn, Ainsworth Jonathan, Williams Ian, Sweeney John, Freedman Andrew, Johnson Margaret, Pantaleo Giuseppe, Kinloch-de Loes Sabine

Abstract excerpt

BACKGROUND: Intervention with antiretroviral treatment (ART) and control of viral replication at the time of HIV-1 seroconversion may curtail cumulative immunological damage. We have therefore hypothesized that ART maintenance over a very prolonged period in HIV-1 seroconverters could induce an immuno-virological status similar to that of HIV-1 long-term non-progressors (LTNPs). METHODOLOGY/PRINCIPAL FINDINGS: We...

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PMID: 21483676
DOI: 10.1371/journal.pone.0018164
PMCID: PMC3071718

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TNF

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