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Article

Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development.

BMC developmental biology - 22 Jan 2009

Schuster-Gossler Karin, Harris Belinda, Johnson Kenneth R, Serth Jürgen, Gossler Achim

Abstract excerpt

BACKGROUND: The evolutionarily conserved Notch signalling pathway regulates multiple developmental processes in a wide variety of organisms. One critical posttranslational modification of Notch for its function in vivo is the addition of O-linked fucose residues by protein O-fucosyltransferase 1 (POFUT1). In addition, POFUT1 acts as a chaperone and is required for Notch trafficking. Mouse embryos lacking POFUT1...

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Topics

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Share to Body Patterning
Share to Embryo, Mammalian

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fucosyltransferases

Share to Gene Expression Regulation, Developmental

Share to Glycosyltransferases

Share to Immunohistochemistry

Share to Mesoderm

Share to Receptors, Notch

Source

Open in PubMed Open full text

Identifiers

PMID: 19161597
DOI: 10.1186/1471-213X-9-6
PMCID: PMC2637848

Genes

POFUT1
LFNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development.PMID 19161597Read ↗

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