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Article

Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment

21 Dec 2004

Abstract excerpt

Both nuclear factor erythroid 2 45 kDa subunit (p45) and BTB and CNC homolog 1 (Bach) transcription factors can form dimers with one of the small Maf proteins, and these heterodimers bind to the musculoaponeurotic fibrosarcoma oncogene (Maf) recognition element (MARE). MARE is known to act as a critical cis-regulatory element of erythroid and megakaryocytic genes. Although detailed analyses of p45-null mutant...

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PMID: 15613547
DOI: 10.1182/blood-2004-07-2826

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