A polymorphism rs3746444 within the pre-miR-499 alters the maturation of miR-499-5p and its antiapoptotic function.

doi:10.1111/jcmm.13813

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Article

A polymorphism rs3746444 within the pre-miR-499 alters the maturation of miR-499-5p and its antiapoptotic function.

Journal of cellular and molecular medicine - 1 Nov 2018

Ding Wei, Li Mengyang, Sun Teng, Han Di, Guo Xiaoci, Chen Xiao, Wan Qinggong, Zhang Xuejuan, Wang Jianxun

Abstract excerpt

microRNAs (miRNAs) are non-coding RNAs that function as post-transcriptional regulators of cardiac development and cardiovascular diseases. Single nucleotide polymorphisms (SNPs) in miRNA genes are a novel class of genetic variations in the human genome that confer the risk of cardiovascular diseases. Here, we identified a polymorphism A→G (rs3746444) in miR-499 precursor (pre-miR-499) that affects the maturation...

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PMID: 30102014
DOI: 10.1111/jcmm.13813
PMCID: PMC6201352

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