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Article

Structural implication for the impaired binding of W150A mutant LOX-1 to oxidized low density lipoprotein, OxLDL.

Biochimica et biophysica acta - 1 May 2012

Nakano Shogo, Sugihara Mamoru, Yamada Risato, Katayanagi Katsuo, Tate Shin-ichi

Abstract excerpt

Lectin-like oxidized lipoprotein (OxLDL) receptor 1, LOX-1, is the major OxLDL receptor expressed on vascular endothelial cells. We have previously reported the ligand-recognition mode of LOX-1 based on the crystal structure of the ligand binding domain (C-type lectin-like domain, CTLD) and surface plasmon resonance analysis, which suggested that the functional significance of the CTLD dimer (the 'canonical'...

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Identifiers

PMID: 22369967
DOI: 10.1016/j.bbapap.2012.02.003

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LOX

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