Article
Variations of the ataxia telangiectasia mutated gene in patients with chronic lymphocytic leukemia lack substantial impact on progression-free survival and overall survival: a Cancer and Leukemia Group B study.
Leukemia & lymphoma - 1 Sept 2012
Lozanski Gerard, Ruppert Amy S, Heerema Nyla A, Lozanski Arletta, Lucas David M, Gordon Amber, Gribben John G, Morrison Vicki A, Rai Kanti M, Marcucci Guido, Larson Richard A, Byrd John C
Abstract excerpt
The impact of mutation of the ATM (ataxia telangiectasia mutated) gene in chronic lymphocytic leukemia (CLL) treatment outcome has not been examined. We studied ATM mutations in 73 patients treated with fludarabine and rituximab. ATM gene mutation analysis was performed using temperature gradient capillary electrophoresis. The impact of detected variants on overall survival (OS) and progression-free survival...
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