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Article

Genome-Wide Linkage Analysis of Large Multiple Multigenerational Families Identifies Novel Genetic Loci for Coronary Artery Disease.

Scientific reports - 14 Jul 2017

Guo Yang, Wang Fan, Li Lin, Gao Hanxiang, Arckacki Stephen, Wang Isabel Z, Barnard John, Ellis Stephen, Hubbard Carlos, Topol Eric J, Chen Qiuyun, Wang Qing K

Abstract excerpt

Coronary artery disease (CAD) is the leading cause of death, and genetic factors contribute significantly to risk of CAD. This study aims to identify new CAD genetic loci through a large-scale linkage analysis of 24 large and multigenerational families with 433 family members (GeneQuest II). All family members were genotyped with markers spaced by every 10 cM and a model-free nonparametric linkage (NPL-all)...

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Source

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Identifiers

PMID: 28710368
DOI: 10.1038/s41598-017-05381-2
PMCID: PMC5511258

Genes

CAD
NPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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