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Article

A distinct subset of atypical Spitz tumors is characterized by BRAF mutation and loss of BAP1 expression.

The American journal of surgical pathology - 1 Jun 2012

Wiesner Thomas, Murali Rajmohan, Fried Isabella, Cerroni Lorenzo, Busam Klaus, Kutzner Heinz, Bastian Boris C

Abstract excerpt

We recently reported that germline mutations in BAP1 cause a familial tumor syndrome characterized by high penetrance for melanocytic tumors with distinct clinical and histologic features. Melanocytic neoplasms in affected individuals harbored BRAF mutations, showed loss of BAP1 expression, and h...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22367297
DOI: 10.1097/PAS.0b013e3182498be5
PMCID: PMC3354018

Genes

BAP1
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22367297-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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