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Article

BAP1-deficient and VE1-negative atypical Spitz tumor.

Journal of cutaneous pathology - 1 Aug 2015

Requena Celia, Sanz Virginia, Nagore Eduardo, García-Casado Zaida, Rubio Luis, Guillén Carlos, Kutzner Heinz

Abstract excerpt

Atypical Spitz tumor with loss of BAP1 or Wiesner nevus is a peculiar variant of intradermal spitzoid melanocytic neoplasm composed of epithelioid melanocytes with a sheet-like growth pattern, abundant infiltrating lymphocytes and rare or absent mitotic activity. This subset of atypical spitzoid tumors is characterized by the BRAF(V600E) mutation and loss of BAP1 expression. Recognition of these lesions is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25953246
DOI: 10.1111/cup.12519

Genes

BAP1
BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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