Article
Genomic aberrations in spitzoid melanocytic tumours and their implications for diagnosis, prognosis and therapy.
Pathology - 1 Feb 2016
Wiesner Thomas, Kutzner Heinz, Cerroni Lorenzo, Mihm Martin C, Busam Klaus J, Murali Rajmohan
Abstract excerpt
Histopathological evaluation of melanocytic tumours usually allows reliable distinction of benign melanocytic naevi from melanoma. More difficult is the histopathological classification of Spitz tumours, a heterogeneous group of tumours composed of large epithelioid or spindle-shaped melanocytes. Spitz tumours are biologically distinct from conventional melanocytic naevi and melanoma, as exemplified by their...
Topics
- Animals
- Chromosome Aberrations
- Genomics
- Humans
- Melanoma
- Mutation
- Nevus, Epithelioid and Spindle Cell
- Nevus, Pigmented
- Phosphotransferases
- Prognosis
- Proto-Oncogene Proteins
- Recombination, Genetic
- Skin
- Skin Neoplasms
