Article
The RNA-binding protein, ZFP36L2, influences ovulation and oocyte maturation.
PloS one - 1 Jan 2014
Ball Christopher B, Rodriguez Karina F, Stumpo Deborah J, Ribeiro-Neto Fernando, Korach Kenneth S, Blackshear Perry J, Birnbaumer Lutz, Ramos Silvia B V
Abstract excerpt
ZFP36L2 protein destabilizes AU-rich element-containing transcripts and has been implicated in female fertility. In the C57BL/6NTac mouse, a mutation in Zfp36l2 that results in the decreased expression of a form of ZFP36L2 in which the 29 N-terminal amino acid residues have been deleted, ΔN-ZFP36L2, leads to fertilized eggs that arrest at the two-cell stage. Interestingly, homozygous ΔN-Zfp36l2 females in the...
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