Article
A placental growth factor is silenced in mouse embryos by the zinc finger protein ZFP568.
Science (New York, N.Y.) - 19 May 2017
Yang Peng, Wang Yixuan, Hoang Don, Tinkham Matthew, Patel Anamika, Sun Ming-An, Wolf Gernot, Baker Mairead, Chien Huan-Chieh, Lai Kuan-Yu Nick, Cheng Xiaodong, Shen Che-Kun James, Macfarlan Todd S
Abstract excerpt
Insulin-like growth factor 2 (IGF2) is the major fetal growth hormone in mammals. We identify zinc finger protein 568 (ZFP568), a member of the rapidly evolving Kruppel-associated box-zinc finger protein (KRAB-ZFP) family linked primarily to silencing of endogenous retroelements, as a direct repressor of a placental-specific Igf2 transcript (designated Igf2-P0) in mice. Loss of Zfp568, which causes gastrulation...
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