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Article

Identification and characterization of a novel bipartite nuclear localization signal in the hepatitis B virus polymerase.

World journal of gastroenterology - 28 Nov 2013

Lupberger Joachim, Schaedler Stephanie, Peiran Alexander, Hildt Eberhard

Abstract excerpt

AIM: To characterize the nuclear import of hepatitis B virus (HBV) polymerase (P) and its relevance for the viral life cycle. METHODS: Sequence analysis was performed to predict functional motives within P. Phosphorylation of P was analyzed by in vitro phosphorylation. Phosphorylation site and nuclear localization signal (NLS) were destroyed by site directed mutagenesis. Functionality of the identified NLS was...

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Source

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Identifiers

PMID: 24307793
DOI: 10.3748/wjg.v19.i44.8000
PMCID: PMC3848147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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