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Article

[Construction and functional characterization of a monocistronic replicon based on the HCV genotype 2a promotor].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology - 1 Feb 2012

Li Xue-Li, Lei Yu, Zhong Shan, Peng Feng-Ying, Zhou Zhi, Li Kui, Ren Hong

Abstract excerpt

To construct a hepatitis C virus (HCV) genotype 2a monocistronic replicon and investigate its replication capabilities in the human hepatocarcinoma cell lines, Huh7.5 and Huh7.1, in order to determine its potential as a molecular tool for future in vitro studies of HCV replication and selection studies for putative anti-HCV drugs. Site-directed mutagenesis was used to delete the Core-E1-E2-p7-NS2 fragment (about...

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Source

Identifiers

PMID: 22464780
DOI: 10.3760/cma.j.issn.1007-3418.2012.02.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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