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Article

Differentiation of Caco-2 cells requires both transcriptional and post-translational down-regulation of Myc.

Differentiation; research in biological diversity - 1 Mar 2012

Leoni Bruno Daniele, Natoli Manuela, Nardella Marta, Bucci Barbara, Zucco Flavia, D'Agnano Igea, Felsani Armando

Abstract excerpt

Caco-2 cancer cell line is widely used to reproduce in vitro the differentiation of absorptive enterocytes of human intestinal epithelium. This cell line, when cultured over confluence for 21 days, spontaneously undergoes cell cycle arrest and differentiates with the formation of a polarized ente...

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Source

Identifiers

PMID: 22364879
DOI: 10.1016/j.diff.2011.10.005

Genes

APC
MYC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22364879-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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