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Article

Polyamines regulate E-cadherin transcription through c-Myc modulating intestinal epithelial barrier function.

American journal of physiology. Cell physiology - 1 Apr 2009

Liu Lan, Guo Xin, Rao Jaladanki N, Zou Tongtong, Xiao Lan, Yu Tingxi, Timmons Jennifer A, Turner Douglas J, Wang Jian-Ying

Abstract excerpt

The integrity of the intestinal epithelial barrier depends on intercellular junctions that are highly regulated by numerous extracellular and intracellular factors. E-cadherin is found primarily at the adherens junctions in the intestinal mucosa and mediates strong cell-cell contacts that have a functional role in forming and regulating the epithelial barrier. Polyamines are necessary for E-cadherin expression,...

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Identifiers

PMID: 19176757
DOI: 10.1152/ajpcell.00620.2008
PMCID: PMC2670658

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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