Article
Loss of Apm1, the micro1 subunit of the clathrin-associated adaptor-protein-1 complex, causes distinct phenotypes and synthetic lethality with calcineurin deletion in fission yeast.
Molecular biology of the cell - 1 Jun 2004
Kita Ayako, Sugiura Reiko, Shoji Hiromi, He Yi, Deng Lu, Lu Yabin, Sio Susie O, Takegawa Kaoru, Sakaue Motoyoshi, Shuntoh Hisato, Kuno Takayoshi
Abstract excerpt
Calcineurin is a highly conserved regulator of Ca(2+) signaling in eukaryotes. In fission yeast, calcineurin is not essential for viability but is required for cytokinesis and Cl(-) homeostasis. In a genetic screen for mutations that are synthetically lethal with calcineurin deletion, we isolated a mutant, cis1-1/apm1-1, an allele of the apm1(+) gene that encodes a homolog of the mammalian micro1A subunit of the...
Topics
- Acid Phosphatase
- Adaptor Protein Complex 1
- Adaptor Protein Complex mu Subunits
- Amino Acid Sequence
- Calcineurin
- Cell Wall
- Cytokinesis
- Endocytosis
- Endosomes
- Gene Deletion