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Article

Association of mitochondrial DNA variations with lung cancer risk in a Han Chinese population from southwestern China.

PloS one - 1 Jan 2012

Zheng Shizhen, Qian Pin, Li Fuxiang, Qian Guisheng, Wang Changzheng, Wu Guoming, Li Qi, Chen Yan, Li Jin, Li Haining, He Binfeng, Ji Fuyun

Abstract excerpt

Mitochondrial DNA (mtDNA) is particularly susceptible to oxidative damage and mutation due to the high rate of reactive oxygen species (ROS) production and limited DNA-repair capacity in mitochondrial. Previous studies demonstrated that the increased mtDNA copy number for compensation for damage, which was associated with cigarette smoking, has been found to be associated with lung cancer risk among heavy...

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Identifiers

PMID: 22363619
DOI: 10.1371/journal.pone.0031322
PMCID: PMC3283641

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