Article
Smoking-associated mitochondrial DNA mutations and lipid peroxidation in human lung tissues.
American journal of respiratory cell and molecular biology - 1 Dec 1998
Fahn H J, Wang L S, Kao S H, Chang S C, Huang M H, Wei Y H
Abstract excerpt
To investigate the effect of cigarette smoking on mitochondrial DNA (mtDNA) mutation and lipid peroxidation in lung tissues, 152 samples from lung resections were collected. A novel deletion of 4,839 bp of mtDNA was found in 80 (52.6%) of the 152 lung samples. The breakpoints of the 4,839-bp mtDN...
Topics
- Adult
- Aged
- Aged, 80 and over
- DNA, Mitochondrial
- Female
- Gene Deletion
- Humans
- Infant, Newborn
- Lipid Peroxidation
- Lung
- Male
- Malondialdehyde
- Middle Aged
- Mutation
- Repetitive Sequences, Nucleic Acid
- Sequence Analysis, DNA
- Smoking