Article
Smoking-associated mitochondrial DNA mutations and lipid peroxidation in human lung tissues.
American journal of respiratory cell and molecular biology - 1 Dec 1998
Fahn H J, Wang L S, Kao S H, Chang S C, Huang M H, Wei Y H
Abstract excerpt
To investigate the effect of cigarette smoking on mitochondrial DNA (mtDNA) mutation and lipid peroxidation in lung tissues, 152 samples from lung resections were collected. A novel deletion of 4,839 bp of mtDNA was found in 80 (52.6%) of the 152 lung samples. The breakpoints of the 4,839-bp mtDNA deletion were flanked by a nine-nucleotide direct repeat (5'-CATACACAA-3'). The frequency of occurrence and the...
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