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Transforming Growth Factor-β and Notch Signaling Mediate Stem Cell Differentiation into Smooth Muscle Cells

9 Feb 2010

Abstract excerpt

The differentiation of stem cells into smooth muscle cells (SMCs) plays an important role in vascular development and remodeling. In addition, stem cells represent a potential source of SMCs for regenerative medicine applications such as constructing vascular grafts. Previous studies have suggested that various biochemical factors, including transforming growth factor-beta (TGF-beta) and the Notch pathway, may...

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Angiogenesis and VEGF in Cancer
Developmental Biology and Gene Regulation
Mesenchymal stem cell research

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PMID: 20146266
DOI: 10.1002/stem.319

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