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Article

Double CEBPA mutations are prognostically favorable in non-M3 acute myeloid leukemia patients with wild-type NPM1 and FLT3-ITD.

International journal of clinical and experimental pathology - 1 Jan 2014

Wen Xiang-Mei, Lin Jiang, Yang Jing, Yao Dong-Ming, Deng Zhao-Qun, Tang Chun-Yan, Xiao Gao-Fei, Yang Lei, Ma Ji-Chun, Hu Jia-Bo, Qian Wei, Qian Jun

Abstract excerpt

This study is aimed to investigate the pattern of CEBPA mutations and its clinical significance in Chinese non-M3 acute myeloid leukemia (AML) patients. The entire coding region of CEBPA gene was amplified by PCR and then sequenced in samples from 233 non-M3 AML patients. Fifty mutations were identified in 37 (15.8%) patients with eleven (4.7%) double mutated CEBPA (dmCEBPA) and twenty-six (11.1%) single mutated...

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Source

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Identifiers

PMID: 25400766
PMCID: PMC4230151

Genes

FLT3
NPM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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