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Cyclin dependent kinases in cancer

1 May 2012

Abstract excerpt

Cell cycle progression through each phase is regulated by heterodimers formed by cyclin-dependent kinases (CDKs) and their regulatory partner proteins, the cyclins. Together they coordinate the cellular events through cell cycle. De-regulation of cell-cycle control due to aberrant CDK activity is a common feature of most cancer types. Intensive research on small molecules that target cell cycle regulatory...

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PMID: 22361734
DOI: 10.4161/cbt.19589

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