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Article

Suppression of β1-integrin in gonadotropin-releasing hormone cells disrupts migration and axonal extension resulting in severe reproductive alterations.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Nov 2012

Parkash Jyoti, Cimino Irene, Ferraris Nicoletta, Casoni Filippo, Wray Susan, Cappy Hélène, Prevot Vincent, Giacobini Paolo

Abstract excerpt

Reproduction in mammals is dependent on the function of hypothalamic neurons whose axons project to the hypothalamic median eminence (ME) where they release gonadotropin-releasing hormone (GnRH) into a specialized capillary network for delivery to the anterior pituitary. These neurons originate prenatally in the nasal placode and migrate into the forebrain along the olfactory-vomeronasal nerves. The complex...

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Source

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Identifiers

PMID: 23175850
DOI: 10.1523/JNEUROSCI.3057-12.2012
PMCID: PMC5238668

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Suppression of β1-integrin in gonadotropin-releasing hormone cells disrupts migration and axonal extension resulting in severe reproductive alterations.PMID 23175850Read ↗

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