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Therapy-Induced Tumor Cell Senescence: Mechanisms and Circumvention.

Biochemistry. Biokhimiia - 1 Jan 2023

Zamkova Maria A, Persiyantseva Nadezhda A, Tatarskiy Victor V, Shtil Alexander A

Abstract excerpt

Plasticity of tumor cells (multitude of molecular regulation pathways) allows them to evade cytocidal effects of chemo- and/or radiation therapy. Metabolic adaptation of the surviving cells is based on transcriptional reprogramming. Similarly to the process of natural cell aging, specific features of the survived tumor cells comprise the therapy-induced senescence phenotype. Tumor cells with this phenotype differ...

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PMID: 37068872
DOI: 10.1134/S000629792301008X

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