Article
Bafilomycin A1 triggers proliferative potential of senescent cancer cells in vitro and in NOD/SCID mice.
Oncotarget - 7 Feb 2017
Was Halina, Barszcz Kamila, Czarnecka Joanna, Kowalczyk Agata, Bernas Tytus, Uzarowska Ewelina, Koza Paulina, Klejman Agata, Piwocka Katarzyna, Kaminska Bozena, Sikora Eva
Abstract excerpt
Anticancer therapies that induce DNA damage tend to trigger senescence in cancer cells, a process known as therapy-induced senescence (TIS). Such cells may undergo atypical divisions, thus contributing to tumor re-growth. Accumulation of senescent cancer cells reduces survival of patients after chemotherapy. As senescence interplays with autophagy, a dynamic recycling process, we sought to study whether...
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