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Mitochondrial DNA damage induces apoptosis in senescent cells

18 Jul 2013

Abstract excerpt

Senescence is a cellular response to damage and stress. The senescence response prevents cancer by suppressing the proliferation of cells with a compromised genome and contributes to optimal wound healing in normal tissues. Persistent senescent cells are also thought to drive aging and age-associated pathologies through their secretion of inflammatory factors that modify the tissue microenvironment and alter the...

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PMID: 23868060
DOI: 10.1038/cddis.2013.199

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