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Article

A longitudinal study of prediagnostic metabolic biomarkers and the risk of molecular subtypes of colorectal cancer.

Scientific reports - 24 Mar 2020

Myte Robin, Harlid Sophia, Sundkvist Anneli, Gylling Björn, Häggström Jenny, Zingmark Carl, Burström Anna Löfgren, Palmqvist Richard, Guelpen Bethany Van

Abstract excerpt

Body fatness increases the risk of colorectal cancer (CRC). Insulin resistance and altered adipokines are potential mechanisms, but previous biomarker studies have been inconsistent. Intertumoral heterogeneity might provide an explanation. We investigated insulin, C-peptide, adiponectin, and leptin in relation to CRC molecular subtypes using a nested case-control design (1010 cases, 1010 matched controls, median...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32210264
DOI: 10.1038/s41598-020-62129-1
PMCID: PMC7093429

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