Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Saquinavir inhibits the malaria parasite's chloroquine resistance transporter.

Antimicrobial agents and chemotherapy - 1 May 2012

Martin Rowena E, Butterworth Alice S, Gardiner Donald L, Kirk Kiaran, McCarthy James S, Skinner-Adams Tina S

Abstract excerpt

The antiretroviral protease inhibitors (APIs) ritonavir, saquinavir, and lopinavir, used to treat HIV infection, inhibit the growth of Plasmodium falciparum at clinically relevant concentrations. Moreover, it has been reported that these APIs potentiate the activity of chloroquine (CQ) against this parasite in vitro. The mechanism underlying this effect is not understood, but the degree of chemosensitization...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chloroquine
Share to Drug Combinations

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Synergism

Share to HIV Protease Inhibitors

Share to Lopinavir

Share to Ritonavir

Share to Saquinavir

Share to Tritium

Source

Open in PubMed Open full text

Identifiers

PMID: 22354298
DOI: 10.1128/AAC.00166-12
PMCID: PMC3346596

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Saquinavir inhibits the malaria parasite's chloroquine resistance transporter.PMID 22354298Read ↗

Verapamil-Sensitive Transport of Quinacrine and Methylene Blue via the Plasmodium falciparum Chloroquine Resistance Transporter Reduces the Parasite's Susceptibility to these Tricyclic Drugs.Semantic proximity Read ↗

Know your enemy: understanding the role of PfCRT in drug resistance could lead to new antimalarial tactics.Semantic proximity Read ↗

Chloroquine transport via the malaria parasite's chloroquine resistance transporter.Semantic proximity Read ↗

PfCRT and its role in antimalarial drug resistance.Semantic proximity Read ↗

Mutations in the Plasmodium falciparum chloroquine resistance transporter, PfCRT, enlarge the parasite's food vacuole and alter drug sensitivities.Semantic proximity Read ↗

Evidence for a central role for PfCRT in conferring Plasmodium falciparum resistance to diverse antimalarial agents.Semantic proximity Read ↗

Geographic patterns of Plasmodium falciparum drug resistance distinguished by differential responses to amodiaquine and chloroquine.Semantic proximity Read ↗

Functional characteristics of the malaria parasite's "chloroquine resistance transporter": implications for chemotherapy.Semantic proximity Read ↗

PfCRT-mediated drug transport in malarial parasites.Semantic proximity Read ↗

Optimization of 4-aminoquinoline/clotrimazole-based hybrid antimalarials: further structure-activity relationships, in vivo studies, and preliminary toxicity profiling.Semantic proximity Read ↗

Metabolic QTL Analysis Links Chloroquine Resistance in Plasmodium falciparum to Impaired Hemoglobin CatabolismSemantic proximity Read ↗

Altered Drug Transport by Plasmodium falciparum Chloroquine Resistance Transporter Isoforms Harboring Mutations Associated with Piperaquine Resistance.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.