Article
TLR3 essentially promotes protective class I-restricted memory CD8⁺ T-cell responses to Aspergillus fumigatus in hematopoietic transplanted patients.
Blood - 26 Jan 2012
Carvalho Agostinho, De Luca Antonella, Bozza Silvia, Cunha Cristina, D'Angelo Carmen, Moretti Silvia, Perruccio Katia, Iannitti Rossana G, Fallarino Francesca, Pierini Antonio, Latgé Jean-Paul, Velardi Andrea, Aversa Franco, Romani Luigina
Abstract excerpt
Aspergillus fumigatus is a model fungal pathogen and a common cause of severe infections and diseases. CD8⁺ T cells are present in the human and murine T-cell repertoire to the fungus. However, CD8⁺ T-cell function in infection and the molecular mechanisms that control their priming and differentiation into effector and memory cells in vivo remain elusive. In the present study, we report that both CD4⁺ and CD8⁺ T...
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