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CD44 and β3 Integrin Organize Two Functionally Distinct Actin-based Domains in Osteoclasts

27 Sept 2007

Abstract excerpt

The actin cytoskeleton of mature osteoclasts (OCs) adhering to nonmineralized substrates is organized in a belt of podosomes reminiscent of the sealing zone (SZ) found in bone resorbing OCs. In this study, we demonstrate that the belt is composed of two functionally different actin-based domains: podosome cores linked with CD44, which are involved in cell adhesion, and a diffuse cloud associated with beta3...

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PMID: 17898081
DOI: 10.1091/mbc.e07-04-0378

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